阿普唑仑对小鼠T细胞免疫抑制性手术应激反应的影响。
Effects of alprazolam on T-cell immunosuppressive response to surgical stress in mice.
作者信息
Freire-Garabal M, Belmonte A, Orallo F, Couceiro J, Núñez M J
机构信息
Department of Pharmacology, Faculty of Medicine, University of Santiago de Compostela, Spain.
出版信息
Cancer Lett. 1991 Jul 4;58(3):183-7. doi: 10.1016/0304-3835(91)90098-3.
PMID:1649692
Abstract
Mice submitted to surgical stress induced by laparotomy and treated with chronic alprazolam (1 mg/kg) showed a reduction in stress-induced suppression of thymus and spleen cellularity, as well as in peripheral T lymphocyte population. The blastic response of spleen lymphoid cells was also assessed and found to partially supress the inhibitory effect of surgery.
摘要
接受剖腹手术诱导的手术应激并接受慢性阿普唑仑（1毫克/千克）治疗的小鼠，其应激诱导的胸腺和脾脏细胞数量抑制以及外周T淋巴细胞群体减少。还评估了脾脏淋巴细胞的增殖反应，发现其部分抑制了手术的抑制作用。
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