氟西汀对小鼠应激免疫抑制反应的影响。

Effects of fluoxetine on the immunosuppressive response to stress in mice.

作者信息

Freire-Garabal M, Nuñez M J, Losada C, Pereiro D, Riveiro M P, González-Patiño E, Mayán J M, Rey-Mendez M

机构信息

Department of Pharmacology, University of Santiago de Compostela, Spain.

出版信息

Life Sci. 1997;60(26):PL403-13. doi: 10.1016/s0024-3205(97)00329-9.

DOI:10.1016/s0024-3205(97)00329-9

PMID:9199489

Abstract

Mice exposed to a chronic auditory stressor and treated with fluoxetine (5 mg/kg) showed a reduction in stress-induced suppression of thymus and spleen cellularity, and in peripheral T lymphocyte population. The blastogenic response of spleen lymphoid cells and the delayed type hypersensitivity response (DTH) to sheep red blood cells (SRBC) were also assessed and fluoxetine was found to partially reverse the inhibitory effect of stress on both parameters.

摘要

暴露于慢性听觉应激源并接受氟西汀（5毫克/千克）治疗的小鼠，其应激诱导的胸腺和脾脏细胞数量抑制以及外周T淋巴细胞数量均有所减少。还评估了脾脏淋巴细胞的增殖反应和对绵羊红细胞（SRBC）的迟发型超敏反应（DTH），发现氟西汀可部分逆转应激对这两个参数的抑制作用。