Caraceni T A, Girotti F, Giovannini P, Pederzoli M, Parati E A
Ital J Neurol Sci. 1980 Jun;1(3):155-61. doi: 10.1007/BF02335845.
Apomorphine, bromocryptine, lysuride, diazepam and cyproheptadine were administered to 11 patients with Huntington's disease (HD). The evaluation of the pharmacologic activity of different drugs on abnormal involuntary movements (AIM) was determined by means of an arbitrary clinical method. Apomorphine, diazepam and cyproheptadine succeeded in improving the AIM, while bromocryptine and lysuride did not modify the clinical pattern or provoked (bromocryptine) a worsening in some patients. The growth hormone (GH) responses to apomorphine and bromocryptine were determined in 6 patients. The relationship between clinical, endocrine results and pharmacologic action of apomorphine is discussed, suggesting that the reducing effect of apomorphine on AIM of HD may be due to its sedative action.
将阿扑吗啡、溴隐亭、麦角酰二乙胺、地西泮和赛庚啶给予11例亨廷顿舞蹈症（HD）患者。通过一种任意的临床方法来评估不同药物对异常不自主运动（AIM）的药理活性。阿扑吗啡、地西泮和赛庚啶成功改善了AIM，而溴隐亭和麦角酰二乙胺未改变临床症状，或（溴隐亭）在一些患者中导致病情恶化。测定了6例患者对阿扑吗啡和溴隐亭的生长激素（GH）反应。讨论了阿扑吗啡的临床、内分泌结果与药理作用之间的关系，提示阿扑吗啡对HD的AIM的减轻作用可能归因于其镇静作用。
