Handley J M, Maw R D, Lawther H, Horner T, Bharucha H, Dinsmore W W
Department of Genitourinary Medicine, Royal Victoria Hospital, Belfast, Northern Ireland.
Sex Transm Dis. 1992 Jul-Aug;19(4):225-9. doi: 10.1097/00007435-199207000-00008.
In this study, 58 consecutive patients with primary anogenital warts were selected from patients attending a genitourinary clinic. Patients were grouped on the basis of clinical lesion site, i.e. patients with genital warts only, patients with perianal or anal canal warts only, and patients with concurrent perianal and genital warts. Of these patients, 38% of the men (12/31) and 33.3% of the women (9/27) had other anogenital infections, such as nonspecific urethritis (NSU) or nonspecific genital infection, which were the most common. Of the patients who had perianal warts, 37% of the men (7/19) and 25% of the women (4/16) also had warts in the anal canal. Of the women who had anogenital warts, 63% (17/27) had concurrent subclinical low-grade cervical intraepithelial neoplasia (CIN) lesions. Human papilloma virus (HPV) DNA (either 6 or 11, 16 or 18, or 31 or 33 or 35) was detected in 53.3% (40/75) of the anogenital wart biopsy samples, and in 35.2% (6/17) of the low-grade CIN lesions. HPV types 6 or 11 were the most common types in anogenital warts (45.3%); and in CIN lesions HPV types 6 or 11 and 16 or 18 were found with equal frequency (17.6% each). There were no significant differences in HPV types between patients with genital warts and patients with perianal and anal canal warts. Anogenital infection with HPV is multicentric; external anogenital warts and subclinical CIN lesions often exist concurrently. The low prevalence of HPV DNA detected in anogenital warts and CIN biopsy samples may be due to insensitivity of the in situ hybridization technique used in this study.
在本研究中，从一家泌尿生殖诊所的患者中选取了58例连续性原发性肛门生殖器疣患者。患者根据临床病变部位分组，即仅患有生殖器疣的患者、仅患有肛周或肛管疣的患者以及同时患有肛周和生殖器疣的患者。在这些患者中，38%的男性（12/31）和33.3%的女性（9/27）患有其他肛门生殖器感染，如非特异性尿道炎（NSU）或非特异性生殖器感染，这些是最常见的。在患有肛周疣的患者中，37%的男性（7/19）和25%的女性（4/16）在肛管也有疣。在患有肛门生殖器疣的女性中，63%（17/27）同时患有亚临床低度宫颈上皮内瘤变（CIN）病变。在53.3%（40/75）的肛门生殖器疣活检样本以及35.2%（6/17）的低度CIN病变中检测到人类乳头瘤病毒（HPV）DNA（6型或11型、16型或18型、或31型或33型或35型）。HPV 6型或11型是肛门生殖器疣中最常见的类型（45.3%）；在CIN病变中，HPV 6型或11型与16型或18型的检出频率相同（各为17.6%）。生殖器疣患者与肛周和肛管疣患者之间的HPV类型无显著差异。HPV引起的肛门生殖器感染是多中心的；外生殖器疣和亚临床CIN病变常同时存在。在肛门生殖器疣和CIN活检样本中检测到的HPV DNA低患病率可能是由于本研究中使用的原位杂交技术不敏感。
