Padel A F, Venning V A, Evans M F, Quantrill A M, Fleming K A
Nuffield Department of Pathology, John Radcliffe Hospital, Oxford.
BMJ. 1990 Jun 9;300(6738):1491-4. doi: 10.1136/bmj.300.6738.1491.
To identify the types of human papillomaviruses found in anogenital warts in children and to relate these to clinical and social information.
In situ hybridisation using biotin labelled DNA probes to 11 types of human papillomavirus was performed on biopsy specimens from 17 children with anogenital warts.
Nuffield department of pathology and the department of dermatology, Oxford.
Children in one group were referred by general practitioners or paediatricians to the dermatology department, where biopsies were performed. The other children were seen in four different hospitals, and biopsy specimens were submitted to the laboratory at the physician's or pathologist's request.
Of the 17 biopsy specimens, 10 contained cells positive with a probe to a genital human papillomavirus type (types 6 or 11), while six were positive with a skin virus type (types 2 or 3). One was negative. The virus type present bore no relation to the site or appearance of the warts. The virus type did, however, appear to correlate with groups of children. Skin types were commoner in older children (over 4 years), in those with a relative who had skin warts, and in children with warts elsewhere; there was no relation with the child's sex and no suspicion of sexual abuse in these children. These circumstances suggested non-sexual transmission, such as autoinoculation. In contrast, genital types were commoner in girls, in children under 3 years, in children with relatives with genital warts, and in those with no warts elsewhere. Nevertheless, there was suspicion or evidence of sexual abuse in only half these children, suggesting that other routes of transmission--for example, perinatal--might have been implicated.
Anogenital warts in children may contain either skin or genital wart virus type. Although the type of human papillomavirus present may give some indication of the likely mode of transmission, this can be interpreted only in conjunction with all available clinical and social information. The type of virus does not provide proof of the presence or absence of sexual transmission.
确定儿童肛门生殖器疣中发现的人乳头瘤病毒类型，并将其与临床和社会信息相关联。
对17例患有肛门生殖器疣的儿童的活检标本进行了使用生物素标记的DNA探针针对11种人乳头瘤病毒的原位杂交。
牛津大学纳菲尔德病理系和皮肤科。
一组儿童由全科医生或儿科医生转诊至皮肤科进行活检。其他儿童在四家不同医院就诊，活检标本应医生或病理学家要求提交至实验室。
17份活检标本中，10份含有对生殖器人乳头瘤病毒类型（6型或11型）探针呈阳性的细胞，6份对皮肤病毒类型（2型或3型）呈阳性。1份为阴性。所存在的病毒类型与疣的部位或外观无关。然而，病毒类型似乎与儿童群体相关。皮肤型在年龄较大的儿童（4岁以上）、有患皮肤疣亲属的儿童以及其他部位有疣的儿童中更为常见；与儿童性别无关，且这些儿童中无性虐待嫌疑。这些情况提示为非性传播，如自体接种。相比之下，生殖器型在女孩、3岁以下儿童、有患生殖器疣亲属的儿童以及其他部位无疣的儿童中更为常见。然而，这些儿童中仅有半数存在性虐待嫌疑或证据，提示可能涉及其他传播途径——例如围产期传播。
儿童肛门生殖器疣可能含有皮肤或生殖器疣病毒类型。尽管所存在的人乳头瘤病毒类型可能对可能的传播方式有所提示，但这只能结合所有可用的临床和社会信息来解读。病毒类型并不能提供有无性传播的证据。
