Uchida T, Maru N, Furuhata M, Fujino A, Muramoto S, Ishibashi A, Koshiba K, Shiba T, Kikuchi T
Department of Urology, Kitasato University School of Medicine.
Hinyokika Kiyo. 1992 Aug;38(8):973-8.
We present here a production of anti-bacterial zeolite balloon catheter and investigated its potential for controlling urinary tract infection. This anti-bacterial balloon catheter showed a bactericidal effect against Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli in vitro studies. The antibacterial effects were correlated with the concentration of anti-bacterial zeolite and size of catheter. We tried this catheter for 11 various urological patients who needed a long-term indwelling of a balloon catheter for lower urinary tract obstruction and neurogenic bladder. All patients were already indwelled silicon balloon catheter for 3 to 6 months and suffered with complicated urinary tract infection. Nine patients who had this anti-bacterial zeolite balloon catheter indwelled for 3 to 7 months and exchanged every 2 to 4 weeks, and no patient was taking antibiotics during this trial. Two patients (22.2%) showed good results by the urinary tract infection (UTI) criteria and 5 patients (55.4%) showed good effects by doctor's judgment. This anti-bacterial zeolite balloon catheter might be useful for patients who need long-term balloon catheter indwelling.
我们在此展示了一种抗菌沸石球囊导管，并研究了其控制尿路感染的潜力。在体外研究中，这种抗菌球囊导管对铜绿假单胞菌、金黄色葡萄球菌和大肠杆菌显示出杀菌作用。抗菌效果与抗菌沸石的浓度和导管尺寸相关。我们将这种导管应用于11例因下尿路梗阻和神经源性膀胱需要长期留置球囊导管的泌尿外科患者。所有患者均已留置硅胶球囊导管3至6个月，并患有复杂性尿路感染。9例患者留置这种抗菌沸石球囊导管3至7个月，每2至4周更换一次，在此试验期间没有患者使用抗生素。根据尿路感染（UTI）标准，2例患者（22.2%）显示出良好效果，根据医生判断，5例患者（55.4%）显示出良好效果。这种抗菌沸石球囊导管可能对需要长期留置球囊导管的患者有用。
