Bach R, Zardini P
Medizinische Universitätsklinik, Innere Medizin III, Homburg/Saar, Germany.
Am J Cardiol. 1992 Oct 8;70(10):70C-77C. doi: 10.1016/0002-9149(92)91361-7.
Once-daily lisinopril (5-20 mg) was compared with twice-daily captopril (12.5-50 mg) in a double-blind, randomized, parallel-group study of angiotensin-converting enzyme (ACE) inhibition conducted in 31 centers for 12 weeks in patients with heart failure (New York Heart Association class II-III) who were currently receiving digitalis and/or diuretics. The drugs were compared with regard to their effects on exercise duration, measured with bicycle ergometry, and on ectopic activity, measured using Holter monitoring. Both drugs significantly increased exercise duration after both 6 and 12 weeks of randomized treatment. Neither ACE inhibitor had any significant impact on the hourly rate of either ventricular ectopic counts or couplets, nor was there any difference between treatments with regard to the proportions of patients in whom ventricular ectopic counts were reduced. Both drugs were well tolerated, with no differences observed between treatments. Potassium, urea, and creatinine levels remained stable for both treatments throughout the study.
在一项双盲、随机、平行组研究中，将每日一次的赖诺普利（5 - 20毫克）与每日两次的卡托普利（12.5 - 50毫克）进行了比较，该研究为血管紧张素转换酶（ACE）抑制研究，在31个中心开展，为期12周，研究对象为患有心力衰竭（纽约心脏协会II - III级）且正在接受洋地黄和/或利尿剂治疗的患者。比较了这两种药物对通过自行车测力计测量的运动持续时间以及通过动态心电图监测测量的异位活动的影响。在随机治疗6周和12周后，两种药物均显著增加了运动持续时间。两种ACE抑制剂对每小时室性异位搏动计数或成对搏动率均无显著影响，在室性异位搏动计数减少的患者比例方面，治疗组之间也没有差异。两种药物耐受性良好，治疗组之间未观察到差异。在整个研究过程中，两种治疗的钾、尿素和肌酐水平均保持稳定。
