The acute effect of sertindole on brain 5-HT2, D2 and alpha 1 receptors (ex vivo radioreceptor binding studies).

The ability of sertindole to influence the ex vivo binding of 3H-ketanserin, 3H-prazosin and 3H-spiperone to 5-HT2 receptors, alpha 1-adrenoceptors and DA D2 receptors, respectively, in rat brain has been studied after acute treatment. Sertindole is a potent, long acting compound which readily passes the blood-brain barrier. It dose-dependently binds to all three receptors types. In line with in vivo behavioural experiments sertindole has the most pronounced effect on 5-HT2 receptors, lower effect on alpha 1-adrenoceptors and the lowest effect on striatal D2 receptors.