Long M G, Boultbee J E, Langley R, Newlands E S, Begent R H, Bagshawe K D
Department of Medical Oncology, Charing Cross Hospital, London, UK.
Br J Cancer. 1992 Nov;66(5):883-7. doi: 10.1038/bjc.1992.379.
The haemodynamics of the uterine arteries and myometrium were assessed using Doppler ultrasound in forty consecutive patients requiring treatment for invasive mole and choriocarcinoma. The investigations were performed prior to the commencement of chemotherapy and the subjects followed prospectively. The Doppler waveforms from the uterine arteries were analysed using the pulsatility index. It was found that patients with a pulsatility index of 1.1 or less were significantly more likely to develop drug resistance than those with a higher value (P < 0.04). There was no significant association between the pulsatility index and metastatic disease or uterine bleeding. Five out of eight patients who developed drug resistance could have avoided initial inadequate treatment if the Doppler findings were included in the scoring system for selecting chemotherapy for these tumours. It can be concluded that assessment of the uterine arteries using the pulsatility index prior to the treatment of patients with invasive mole and choriocarcinoma is of help in predicting those who will develop drug resistance.
对40例连续因侵袭性葡萄胎和绒毛膜癌需要治疗的患者，使用多普勒超声评估子宫动脉和子宫肌层的血流动力学。在化疗开始前进行检查，并对受试者进行前瞻性随访。使用搏动指数分析子宫动脉的多普勒波形。发现搏动指数为1.1或更低的患者比搏动指数较高的患者发生耐药的可能性显著更高（P<0.04）。搏动指数与转移性疾病或子宫出血之间无显著关联。如果将多普勒检查结果纳入这些肿瘤化疗选择的评分系统，8例发生耐药的患者中有5例本可避免初始的不充分治疗。可以得出结论，在侵袭性葡萄胎和绒毛膜癌患者治疗前，使用搏动指数评估子宫动脉有助于预测哪些患者会发生耐药。
