Keizer J, Maki L W
Institute of Theoretical Dynamics, University of California, Davis 95616.
Biophys J. 1992 Jul;63(1):291-5. doi: 10.1016/S0006-3495(92)81576-X.
The domain model of Ca2+ inactivation of Ca2+ channels, which has been used to explain rapid inactivation of whole cell Ca2+ currents in pancreatic beta cells, is applied to single-time and conditional open probability measurements on guinea pig ventricular myocyte Ca2+ channels. These two measurements greatly constrain the choice of kinetic constants in the model. Calculations with the model provide a simple quantitative explanation of recent experimental results, including a slow increase in the inactivation rate.
钙通道钙失活的域模型已被用于解释胰腺β细胞中全细胞钙电流的快速失活，现应用于豚鼠心室肌细胞钙通道的单次和条件开放概率测量。这两种测量极大地限制了模型中动力学常数的选择。用该模型进行的计算为最近的实验结果提供了一个简单的定量解释，包括失活速率的缓慢增加。
