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钙内流期间细胞膜下钙活性的区室化及其在递质释放中的意义。

Compartmentalization of the submembrane calcium activity during calcium influx and its significance in transmitter release.

作者信息

Simon S M, Llinás R R

出版信息

Biophys J. 1985 Sep;48(3):485-98. doi: 10.1016/S0006-3495(85)83804-2.

DOI:10.1016/S0006-3495(85)83804-2
PMID:2412607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1329362/
Abstract

Quantitative modeling indicates that, in presynaptic terminals, the intracellular calcium concentration profile during inward calcium current is characterized by discrete peaks of calcium immediately adjacent to the calcium channels. This restriction of intracellular calcium concentration suggests a remarkably well specified intracellular architecture such that calcium, as a second messenger, may regulate particular intracellular domains with a great degree of specificity.

摘要

定量建模表明，在突触前终末，内向钙电流期间细胞内钙浓度分布的特征是紧邻钙通道处有离散的钙峰。细胞内钙浓度的这种限制表明存在一种非常明确的细胞内结构，使得钙作为第二信使，可以高度特异性地调节特定的细胞内区域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bc9/1329362/2f1d8cdc3795/biophysj00188-0137-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bc9/1329362/2f1d8cdc3795/biophysj00188-0137-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bc9/1329362/a8695c2dfca8/biophysj00188-0130-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bc9/1329362/3f36ada0580f/biophysj00188-0131-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bc9/1329362/bcb4669b07c3/biophysj00188-0133-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bc9/1329362/2f1d8cdc3795/biophysj00188-0137-a.jpg

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本文引用的文献

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Roles and Sources of Calcium in Synaptic Exocytosis.突触胞吐作用中钙的作用和来源。
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Mutations in DISC1 alter IPR and voltage-gated Ca channel functioning, implications for major mental illness.DISC1基因的突变会改变肌醇磷脂代谢和电压门控钙通道功能，这对重性精神疾病具有重要意义。
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Calcium dependence of neurotransmitter release at a high fidelity synapse.在一个高保真突触中，神经递质释放的钙离子依赖性。
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