Lidow M S, Rakic P
Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510.
Cereb Cortex. 1992 Sep-Oct;2(5):401-16. doi: 10.1093/cercor/2.5.401.
Quantitative in vitro autoradiography was used to study the postnatal development of monoaminergic receptors (D1 and D2 dopaminergic, 5-HT1 and 5-HT2 serotonergic, and alpha 1, alpha 2, and beta noradrenergic sites) in the prefrontal, primary motor, somatosensory, and visual cortex of rhesus monkeys at birth and 1, 2, 4, 8, 12, 36, and 60 months of age. The density of all receptors studied increased rapidly within the first 2 postnatal months to levels as high as two times that recorded in the adults. After the fourth month, receptor density began a decline that subsided around the time of puberty. This course of developmental change was similar in all cortical layers and in all regions examined. However, the magnitude of the transient overproduction and eventual reduction in receptor density varied across the cortical layers and cytoarchitectonic areas in a manner specific to the individual receptor sites. Overall, cortical maturation was associated with the increased tendency of monoaminergic receptors to concentrate preferentially in the superficial cortical layers. The common developmental course of monoaminergic receptors in diverse cytoarchitectonic areas reveals an impressive coordination in the expression and regulation of these functionally relevant proteins in the cerebral cortex during infancy and adolescence.
采用定量体外放射自显影技术，研究了恒河猴出生时以及1、2、4、8、12、36和60月龄时，前额叶、初级运动区、躯体感觉区和视觉皮层中单胺能受体（D1和D2多巴胺能受体、5-HT1和5-HT25-羟色胺能受体以及α1、α2和β去甲肾上腺素能位点）的产后发育情况。所研究的所有受体的密度在出生后的头两个月内迅速增加，达到成人记录水平的两倍之高。在第四个月之后，受体密度开始下降，并在青春期前后趋于平稳。这种发育变化过程在所有皮质层和所有检查区域中都是相似的。然而，受体密度的短暂过度产生和最终降低的幅度在不同皮质层和细胞构筑区域有所不同，且因单个受体位点而异。总体而言，皮质成熟与单胺能受体优先集中在皮质浅层的趋势增加有关。不同细胞构筑区域中单胺能受体的共同发育过程揭示了婴儿期和青春期大脑皮层中这些功能相关蛋白在表达和调节方面令人印象深刻的协调性。
