Lambrecht G, Friebe T, Grimm U, Windscheif U, Bungardt E, Hildebrandt C, Bäumert H G, Spatz-Kümbel G, Mutschler E
Department of Pharmacology, University of Frankfurt, Germany.
Eur J Pharmacol. 1992 Jul 7;217(2-3):217-9. doi: 10.1016/0014-2999(92)90877-7.
We have characterized PPADS (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) as a novel antagonist which selectively blocks P2 purinoceptor-mediated responses in rabbit vas deferens at pre- and postjunctional sites. PPADS did not interact with alpha 1-adrenoceptors, muscarinic M2 and M3 receptors, histamine H1 and adenosine A1 receptors. Thus, PPADS is a novel and useful pharmacological tool to study co-transmission in tissues where ATP and co-existing neurotransmitters act in concert.
我们已将PPADS（磷酸吡哆醛-6-偶氮苯-2'，4'-二磺酸）鉴定为一种新型拮抗剂，它可在兔输精管的节前和节后位点选择性阻断P2嘌呤受体介导的反应。PPADS不与α1-肾上腺素能受体、毒蕈碱M2和M3受体、组胺H1和腺苷A1受体相互作用。因此，PPADS是一种新型且有用的药理学工具，可用于研究ATP与共存神经递质协同作用的组织中的共传递。
