Flood J F, Morley J E, Lanthorn T H
VA Medical Center, Geriatric Research Educational and Clinical Center, St. Louis, MO 63106.
Eur J Pharmacol. 1992 Oct 20;221(2-3):249-54. doi: 10.1016/0014-2999(92)90709-d.
Glycine has been shown to modulate N-methyl-D-aspartate (NMDA) subclass of acidic amino acid receptors which have been implicated in learning and memory. We report that d-cycloserine (DCS) which has a high affinity for the glycine modulatory site in the NMDA receptor complex modulated memory processing in a dose-dependent manner. Mice were trained on a footshock avoidance task. Immediately after training DCS was administered (2.5 to 50 mg/kg s.c.). When retention was tested a week later, 20 mg/kg facilitated retention the best with lower and higher doses be less effective in weakly trained young mice. DCS also facilitated retention in 'senescence-accelerated mice' in which impairment of learning and memory increases with age. DCS had to be administered at higher doses to improve retention as impairment of learning and memory increased.
甘氨酸已被证明可调节酸性氨基酸受体的N-甲基-D-天冬氨酸（NMDA）亚类，该亚类与学习和记忆有关。我们报告称，对NMDA受体复合物中的甘氨酸调节位点具有高亲和力的d-环丝氨酸（DCS）以剂量依赖的方式调节记忆处理。对小鼠进行足部电击回避任务训练。训练后立即给予DCS（2.5至50mg/kg皮下注射）。一周后进行记忆保持测试时，20mg/kg的DCS对记忆保持的促进效果最佳，较低和较高剂量对训练不足的幼鼠效果较差。DCS也促进了“衰老加速小鼠”的记忆保持，这类小鼠的学习和记忆损伤会随着年龄增长而增加。随着学习和记忆损伤的增加，必须给予更高剂量的DCS才能改善记忆保持。
