Quartermain D, Mower J, Rafferty M F, Herting R L, Lanthorn T H
Laboratory of Behavioral Neurology, New York University Medical Center, NY 10016.
Eur J Pharmacol. 1994 May 12;257(1-2):7-12. doi: 10.1016/0014-2999(94)90687-4.
The memory-enhancing potential of D-cycloserine (cycloserine) a partial agonist at the glycine recognition site on the NMDA receptor, was evaluated in mice using a thirst-motivated linear maze learning task. Immediate acute post-training injections (10, 20 and 80 mg/kg) significantly improved retention relative to vehicle-injected controls. Retention was also facilitated if cycloserine (3 and 10 mg/kg but not 20 or 40 mg/kg) was administered 20 min before the retention test. Acquisition of the habit was accelerated if cycloserine (3 mg/kg) was injected 20 min before the training session. Acute post-training injections failed to facilitate retention if mice were pretreated with cycloserine (3 mg/kg) b.i.d. for 15 days before training on the maze. These results indicate that acute cycloserine administration can enhance consolidation and retrieval of memory but that desensitization may occur with chronic exposure to the drug.
D-环丝氨酸（环丝氨酸）作为N-甲基-D-天冬氨酸（NMDA）受体甘氨酸识别位点的部分激动剂，其增强记忆的潜力在小鼠中通过口渴驱动的线性迷宫学习任务进行了评估。训练后立即进行急性注射（10、20和80毫克/千克），与注射赋形剂的对照组相比，显著改善了记忆保持。如果在记忆测试前20分钟给予环丝氨酸（3和10毫克/千克，但不是20或40毫克/千克），也能促进记忆保持。如果在训练前20分钟注射环丝氨酸（3毫克/千克），习惯的形成会加速。如果在迷宫训练前15天对小鼠进行环丝氨酸（3毫克/千克）每日两次预处理，训练后急性注射则无法促进记忆保持。这些结果表明，急性给予环丝氨酸可以增强记忆巩固和提取，但长期接触该药物可能会发生脱敏。
