Stephenson C F, Bridge J A, Sandberg A A
Cancer Center of Southwest Biomedical Research Institute, Scottsdale, AZ 85251.
Hum Pathol. 1992 Nov;23(11):1270-7. doi: 10.1016/0046-8177(92)90295-e.
Diagnostic classification of poorly differentiated, round cell, primitive neuroectodermal neoplasms, including Ewing's sarcoma, peripheral neuroepithelioma, Askin's tumor, and esthesioneuroblastoma, is challenging to the surgical pathologist using conventional histopathologic approaches because of very similar and overlapping morphologic and cytologic features. Furthermore, distinguishing these neoplasms from neuroblastoma, embryonal rhabdomyosarcoma, small cell osteogenic sarcoma, and non-Hodgkin's lymphoma can be difficult. This paper describes and reviews the cytogenetic and molecular genetic changes in these tumors and demonstrates how the ability to detect these changes has enabled a greater understanding of the histogenesis, classification, diagnosis, and prognosis of these neoplasms.
低分化圆形细胞原始神经外胚层肿瘤的诊断分类，包括尤因肉瘤、外周神经上皮瘤、阿斯金瘤和嗅神经母细胞瘤，对于外科病理学家而言，运用传统组织病理学方法颇具挑战性，因为其形态学和细胞学特征极为相似且相互重叠。此外，将这些肿瘤与神经母细胞瘤、胚胎性横纹肌肉瘤、小细胞骨肉瘤及非霍奇金淋巴瘤区分开来也并非易事。本文描述并综述了这些肿瘤的细胞遗传学和分子遗传学变化，并展示了检测这些变化的能力如何有助于更深入地理解这些肿瘤的组织发生、分类、诊断及预后。
