Massung R F, McFadden G, Moyer R W
Department of Immunology and Medical Microbiology, College of Medicine, University of Florida, Gainesville 32610.
J Gen Virol. 1992 Nov;73 ( Pt 11):2903-11. doi: 10.1099/0022-1317-73-11-2903.
Shope fibroma virus (SFV), a tumorigenic poxvirus, has a DNA genome of approximately 160 kb. Previous DNA sequence analysis of SFV has been mainly limited to the terminal inverted repetitions (about 12 kb at each end of the genome) and immediately adjacent regions. We have sequenced a 4 kb fragment located approximately 20 kb from the right-terminal hairpin. Within this region three complete and two partial open reading frames (ORFs) have been identified. Each of the putative polypeptides has sequence similarity to one or more previously identified poxvirus or cellular proteins, with homology to protein kinases, erythrocyte ankyrin and a vaccinia virus virulence-related protein (ORF N1L). The potential significance of these gene products with regard to the phenotype of SFV is discussed.
肖普纤维瘤病毒（SFV）是一种致瘤性痘病毒，其DNA基因组约为160 kb。先前对SFV的DNA序列分析主要局限于末端反向重复序列（基因组两端各约12 kb）及其紧邻区域。我们对位于距右端发夹结构约20 kb处的一个4 kb片段进行了测序。在该区域内已鉴定出三个完整的和两个部分开放阅读框（ORF）。每个推定的多肽与一种或多种先前鉴定的痘病毒或细胞蛋白具有序列相似性，与蛋白激酶、红细胞锚蛋白和一种痘苗病毒毒力相关蛋白（ORF N1L）具有同源性。讨论了这些基因产物对SFV表型的潜在意义。
