Shiozaki M, Eto Y
Nihon Rinsho. 1992 Aug;50(8):1950-5.
Erythroid differentiation factor (EDF), initially found as a differentiation inducer of murine erythroleukemia cells, also acts on normal erythroid progenitors in vitro and in vivo. Furthermore, it is produced endogenously and supporting in vivo erythropoiesis. EDF is structurally identical to activin A, a gonadal protein with follicle stimulating hormone releasing activity, and belongs to TGF beta superfamily. Its activity could be regulated by follistatin, a binding protein with neutralizing activity against EDF/activin A. Molecular cloning of EDF/activin A receptor cDNA has revealed its domain structure characteristic to serine/threonine kinase.
红细胞分化因子（EDF）最初作为小鼠红白血病细胞的分化诱导剂被发现，它在体外和体内也作用于正常的红细胞祖细胞。此外，它是内源性产生的，并支持体内红细胞生成。EDF在结构上与激活素A相同，激活素A是一种具有促卵泡激素释放活性的性腺蛋白，属于转化生长因子β超家族。其活性可被卵泡抑素调节，卵泡抑素是一种对EDF/激活素A具有中和活性的结合蛋白。EDF/激活素A受体cDNA的分子克隆揭示了其丝氨酸/苏氨酸激酶的结构域特征。
