Shiozaki M, Sakai R, Tabuchi M, Nakamura T, Sugino K, Sugino H, Eto Y
Central Research Laboratories, Ajinomoto Company Inc., Kawasaki, Japan.
Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1553-6. doi: 10.1073/pnas.89.5.1553.
Activin A/erythroid differentiation factor (EDF) is a human protein that induces differentiation of a murine erythroleukemia cell (the Friend cell). In this study, we demonstrate that endogenous activin A/EDF activity is present in murine bone marrow and spleen. In addition, this activity is secreted by bone marrow and spleen cells in primary culture. Administration of follistatin (a specific binding protein for activin A/EDF) to mice results in a decrease of erythroid progenitors in the bone marrow and spleen. These findings support the concept that activin A/EDF and follistatin have opposing actions in the regulation of erythropoiesis.
激活素A/红细胞分化因子（EDF）是一种可诱导鼠类红白血病细胞（弗氏细胞）分化的人类蛋白质。在本研究中，我们证明内源性激活素A/EDF活性存在于鼠类骨髓和脾脏中。此外，这种活性由原代培养中的骨髓和脾脏细胞分泌。向小鼠施用卵泡抑素（激活素A/EDF的一种特异性结合蛋白）会导致骨髓和脾脏中红系祖细胞数量减少。这些发现支持了激活素A/EDF和卵泡抑素在红细胞生成调节中具有相反作用这一概念。
