西咪替丁和甲硫米特对豚鼠离体胃黏膜胃酸分泌作用的分析。
Analysis of the actions of cimetidine and metiamide on gastric acid secretion in the isolated guinea pig gastric mucosa.
作者信息
Sjöstrand S E, Ryberg B, Olbe L
出版信息
Naunyn Schmiedebergs Arch Pharmacol. 1977 Jan;296(2):139-42. doi: 10.1007/BF00508465.
PMID:13317
Abstract
Cumulative dose-response curves for histamine were determined on acid secretion from the isolated guinea pig gastric mucosa. Two H2-receptor antagonists-metiamide and cimetidine-behaved like competitive antagonists to histamine on gastric acid secretion in vitro. The isolated guinea pig gastric mucosa seems to be a suitable in vitro model for analysing the action of compounds on receptors involved in acid secretion.
摘要
测定了组胺对豚鼠离体胃黏膜酸分泌的累积剂量反应曲线。两种H2受体拮抗剂——甲硫咪胺和西咪替丁——在体外对组胺引起的胃酸分泌表现出竞争性拮抗剂的作用。豚鼠离体胃黏膜似乎是分析化合物对参与酸分泌的受体作用的合适体外模型。
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