西咪替丁对人胃黏膜中环核苷酸的作用。
The effect of cimetidine on cyclic nucleotides in human gastric mucosa.
作者信息
Mooney P A, Walters J M, McCarthy C F, O'Donnell J M
出版信息
Br J Clin Pharmacol. 1981 Aug;12(2):161-4. doi: 10.1111/j.1365-2125.1981.tb01195.x.
1 Pre-drug concentrations of both nucleotides were similar in patients with or without peptic ulceration. 2 The effect of a singly infusion or repeated oral administration of cimetidine on human gastric mucosal content of cyclic AMP and cyclic GMP was studied. 3 Biopsies from the body of the stomach were taken at endoscopy from patients who were participating in a clinical trial of the value of cimetidine in the treatment of duodenal ulcer. Cyclic nucleotide determinations and histological examinations were performed on biopsies taken before and after cimetidine treatment. 4 Gastric mucosal content of cyclic AMP was significantly increased (P less than 0.01) 20 min after intravenous infusion of 200 mg cimetidine. There was also a significant increase (P less than 0.01) in gastric mucosal cyclic AMP following administration of the drug orally for 28 days. No alterations in gastric mucosal histology were observed following cimetidine treatment. 5 Gastric mucosal content of cyclic GMP was not altered by intravenous drug infusion, or by chronic treatment.
无论有无消化性溃疡，患者用药前两种核苷酸的浓度相似。
研究了西咪替丁单次静脉输注或重复口服给药对人胃黏膜环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）含量的影响。
在内镜检查时，从参与西咪替丁治疗十二指肠溃疡价值临床试验的患者胃体部取活检组织。对西咪替丁治疗前后所取活检组织进行环核苷酸测定和组织学检查。
静脉输注200mg西咪替丁20分钟后，胃黏膜cAMP含量显著增加（P＜0.01）。口服该药28天后，胃黏膜cAMP也显著增加（P＜0.01）。西咪替丁治疗后未观察到胃黏膜组织学改变。
静脉输注药物或长期治疗均未改变胃黏膜cGMP含量。
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