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H2受体拮抗剂雷尼替丁、西咪替丁和甲硫米特对犬胃酸分泌的抑制作用。

Inhibition of gastric acid secretion in the dog by the H2-receptor antagonists, ranitidine, cimetidine, and metiamide.

作者信息

Daly M J, Humphray J M, Stables R

出版信息

Gut. 1980 May;21(5):408-12. doi: 10.1136/gut.21.5.408.

DOI:10.1136/gut.21.5.408
PMID:6107261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1419083/
Abstract

The new H2-receptor antagonist, ranitidine, has been compared with cimetidine and metiamide as an inhibitor of gastric acid secretion in the dog. All three compounds were effective both intravenously or by mouth in inhibiting secretion induced by histamine, pentagastrin, or bethanechol. This inhibition was mainly attributable to a reduction in the volume of secretion, although there was also a significant reduction in the concentration of acid secreted. Metiamide was slightly less active than cimetidine, but ranitidine was four to nine times more potent than cimetidine, depending on the secretagogue used. The antisecretory activity of ranitidine does not result from a limitation in blood flow to the gastric mucosa.

摘要

新型H2受体拮抗剂雷尼替丁已与西咪替丁和甲硫米特进行比较，作为犬胃酸分泌的抑制剂。这三种化合物经静脉注射或口服，对组胺、五肽胃泌素或氨甲酰甲胆碱诱导的分泌均有抑制作用。这种抑制主要归因于分泌量的减少，尽管分泌的酸浓度也有显著降低。甲硫米特的活性略低于西咪替丁，但雷尼替丁的效力比西咪替丁强4至9倍，具体取决于所使用的促分泌剂。雷尼替丁的抗分泌活性并非源于胃黏膜血流量的限制。

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本文引用的文献

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The measurement of dog gastric mucosal blood flow by radioactive aniline clearance compared with amidopyrine clearance.通过放射性苯胺清除率与氨基比林清除率比较来测量犬胃黏膜血流量。
J Physiol. 1973 Feb;229(1):115-31. doi: 10.1113/jphysiol.1973.sp010130.
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Definition and antagonism of histamine H 2 -receptors.组胺H2受体的定义与拮抗作用。
Nature. 1972 Apr 21;236(5347):385-90. doi: 10.1038/236385a0.
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Actions of metiamide, an H2-histamine receptor antagonist, on gastric H+ and pepsin secretion in dogs.H2组胺受体拮抗剂甲硫米特对犬胃H⁺和胃蛋白酶分泌的作用。
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Inhibition of acid secretion in dog by metiamide, a histamine antagonist acting on H2 receptors.甲硫米特（一种作用于H2受体的组胺拮抗剂）对犬胃酸分泌的抑制作用。
Gastroenterology. 1974 Apr;66(4):517-21.
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Clinical experience with metiamide.甲硫米特的临床经验。
Fed Proc. 1976 Jun;35(8):1948-52.
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The effect of (-)-isoprenaline and (+/-)-salbutamol on pepsinogen and acid secretion in the dog.（-）-异丙肾上腺素和（±）-沙丁胺醇对犬胃蛋白酶原和胃酸分泌的影响。
Br J Pharmacol. 1977 Feb;59(2):323-5. doi: 10.1111/j.1476-5381.1977.tb07495.x.
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Potential mechanisms of interaction among secretagogues.促分泌素之间潜在的相互作用机制。
Gastroenterology. 1978 Feb;74(2 Pt 2):348-54.
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Cimetidine in the treatment of duodenal ulcer: review and commentary.西咪替丁治疗十二指肠溃疡：综述与评论。
Gastroenterology. 1978 Feb;74(2 Pt 2):402-6.
9
Safety and efficacy of cimetidine treatment.西咪替丁治疗的安全性和有效性。
Scott Med J. 1977 Oct;22(4):298-9. doi: 10.1177/003693307702200418.
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Inhibition of gastric acid secretion by cimetidine in patients with duodenal ulcer.西咪替丁对十二指肠溃疡患者胃酸分泌的抑制作用。
N Engl J Med. 1975 Aug 21;293(8):371-5. doi: 10.1056/NEJM197508212930802.