H2受体拮抗剂雷尼替丁、西咪替丁和甲硫米特对犬胃酸分泌的抑制作用。
Inhibition of gastric acid secretion in the dog by the H2-receptor antagonists, ranitidine, cimetidine, and metiamide.
作者信息
Daly M J, Humphray J M, Stables R
出版信息
Gut. 1980 May;21(5):408-12. doi: 10.1136/gut.21.5.408.
Abstract
The new H2-receptor antagonist, ranitidine, has been compared with cimetidine and metiamide as an inhibitor of gastric acid secretion in the dog. All three compounds were effective both intravenously or by mouth in inhibiting secretion induced by histamine, pentagastrin, or bethanechol. This inhibition was mainly attributable to a reduction in the volume of secretion, although there was also a significant reduction in the concentration of acid secreted. Metiamide was slightly less active than cimetidine, but ranitidine was four to nine times more potent than cimetidine, depending on the secretagogue used. The antisecretory activity of ranitidine does not result from a limitation in blood flow to the gastric mucosa.
摘要
新型H2受体拮抗剂雷尼替丁已与西咪替丁和甲硫米特进行比较，作为犬胃酸分泌的抑制剂。这三种化合物经静脉注射或口服，对组胺、五肽胃泌素或氨甲酰甲胆碱诱导的分泌均有抑制作用。这种抑制主要归因于分泌量的减少，尽管分泌的酸浓度也有显著降低。甲硫米特的活性略低于西咪替丁，但雷尼替丁的效力比西咪替丁强4至9倍，具体取决于所使用的促分泌剂。雷尼替丁的抗分泌活性并非源于胃黏膜血流量的限制。
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