Veit B C, Feldman J D
J Immunol. 1976 Aug;117(2):646-54.
Impairment of mitogen responses to Con A and LPS and of MLR and MLTR was detected in the spleens of rats bearing syngeneic Moloney sarcoma tumors. Depressed responses of both T cell and Ig+ cell populations were observed. During the observation period of 6 to 10 days post-tumor inoculation when maximal T cell-mediated cytotoxicity was observed in spleen and draining lymph node cells, spleen cells showed marked impairment in response to stimuli mentioned above. By contrast, draining lymph node cell activity was either unaltered or somewhat elevated above the level of activity measured in normal control populations. Data presented in this and an accompanying paper strongly indicate that macrophages are activated as immunosuppressor cells in tumor-bearing rats.
在携带同基因莫洛尼肉瘤肿瘤的大鼠脾脏中，检测到对刀豆蛋白A和脂多糖的丝裂原反应以及混合淋巴细胞反应和混合淋巴细胞培养反应受损。观察到T细胞和Ig +细胞群体的反应均受到抑制。在肿瘤接种后6至10天的观察期内，当在脾脏和引流淋巴结细胞中观察到最大的T细胞介导的细胞毒性时，脾细胞对上述刺激的反应显示出明显受损。相比之下，引流淋巴结细胞活性未改变或略高于正常对照群体中测得的活性水平。本论文及一篇相关论文中呈现的数据强烈表明，巨噬细胞在荷瘤大鼠中被激活为免疫抑制细胞。
