Veit B C, Feldman J D
J Immunol. 1976 Aug;117(2):655-60.
Spleens from tumor-bearing rats contained a population of adherent cells that suppressed lymphocyte responses to Con A and LPS and cell-mediated cytotoxicity (CMC). By use of various fractionation procedures, Ig+ cells, T cells, and null cells were excluded as candidates for the suppressor cell activity. Procedures that removed macrophages abolished the suppressive activity whereas those procedures that enriched for or involved direct addition of macrophages resulted in augmented suppression. On the basis of these results, we conclude that the suppressor elements in spleens of tumor-bearing rats were macrophages.
荷瘤大鼠的脾脏中含有一群贴壁细胞，这些细胞可抑制淋巴细胞对刀豆蛋白A和脂多糖的反应以及细胞介导的细胞毒性（CMC）。通过各种分离程序，排除了Ig⁺细胞、T细胞和裸细胞作为抑制细胞活性候选者的可能性。去除巨噬细胞的程序消除了抑制活性，而那些富集或涉及直接添加巨噬细胞的程序则导致抑制作用增强。基于这些结果，我们得出结论，荷瘤大鼠脾脏中的抑制元件是巨噬细胞。
