下丘脑-免疫相互作用。II. 下丘脑损伤对贴壁脾细胞限制淋巴细胞增殖能力的影响。
Hypothalamic-immune interactions. II. The effect of hypothalamic lesions on the ability of adherent spleen cells to limit lymphocyte blastogenesis.
作者信息
Roszman T L, Cross R J, Brooks W H, Markesbery W R
出版信息
Immunology. 1982 Apr;45(4):737-42.
Abstract
Animals with electrolytic pre-optic and anterior hypothalamic (AHT) lesions show impaired mitogen-induced lymphocyte blastogenesis which is restored by removal of a population of spleen cells with macrophage-like properties. Although suppressor macrophages are detectable in normal and control rats, substantially more activity is present following AHT destruction. Abrogation of lymphocyte activation does not result from increased numbers of splenic macrophages. These data indicate that one mechanism by which neuroimmunomodulation occurs is by induction of a qualitative alteration in the function of naturally occurring suppressor macrophages.
摘要
患有电解视前区和下丘脑前部（AHT）损伤的动物表现出有丝分裂原诱导的淋巴细胞增殖受损，而通过去除一群具有巨噬细胞样特性的脾细胞，这种损伤得以恢复。虽然在正常和对照大鼠中可检测到抑制性巨噬细胞，但在AHT破坏后其活性显著增加。淋巴细胞激活的消除并非源于脾巨噬细胞数量的增加。这些数据表明，神经免疫调节发生的一种机制是诱导天然存在的抑制性巨噬细胞功能发生定性改变。
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