Barton T L, Roush M K, Dever L L
Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284-7766.
Pharmacotherapy. 1992;12(5):413-5.
A 32-year-old man diagnosed with acquired immunodeficiency syndrome and a disseminated cytomegalovirus infection experienced seizures associated with the administration of ganciclovir. Seizures began 1 month after initiation of therapy and worsened with increasing dosages. Despite phenytoin administration, the seizure-like activity subsided only after discontinuing ganciclovir. After rechallenge with ganciclovir the seizures recurred. Although this case was confounded by numerous patient and disease factors, the Naranjo algorithm produced a score of 7, indicating a probable association between ganciclovir and seizure activity.
一名32岁男性被诊断为获得性免疫缺陷综合征并伴有播散性巨细胞病毒感染，在使用更昔洛韦治疗时出现了癫痫发作。癫痫发作始于治疗开始后1个月，并随着剂量增加而加重。尽管使用了苯妥英钠，但只有在停用更昔洛韦后癫痫样活动才消退。再次使用更昔洛韦后癫痫复发。虽然该病例受到众多患者和疾病因素的干扰，但Naranjo算法得出的评分为7分，表明更昔洛韦与癫痫活动之间可能存在关联。
