Costantino L, Albasini A, Rastelli G, Benvenuti S
Dipartimento di Scienze Farmaceutiche, Università di Modena, Italy.
Planta Med. 1992 Aug;58(4):342-4. doi: 10.1055/s-2006-961481.
In view of the pharmacological interest in phenolic substances, we have determined the total amount of anthocyanins and polyphenols present in the berries of several cultivars of Ribes, Rubus, and Vaccinium genera. The in vitro antiradical activity of the crude extracts on chemically-generated superoxide radicals as well as the inhibitory activity towards the enzyme xanthine oxidase were studied. All the crude extracts examined showed a remarkably high activity towards chemically-generated superoxide radicals. The activities were greater than those expected on the basis of the quantities of anthocyanins and polyphenols present in the samples. Furthermore, the extracts showed a certain inhibitory activity towards xanthine oxidase. Ribes nigrum extracts exhibit the highest activity, being the richest in both anthocyanins and polyphenols. On the other hand, Ribes rubrum extracts seem to contain more active substances than the other crude extracts.
鉴于酚类物质在药理学方面的研究价值，我们测定了醋栗属、悬钩子属和越橘属几个品种浆果中花青素和多酚的总量。研究了粗提物对化学产生的超氧自由基的体外抗自由基活性以及对黄嘌呤氧化酶的抑制活性。所有检测的粗提物对化学产生的超氧自由基均表现出显著的高活性。这些活性高于根据样品中花青素和多酚含量所预期的活性。此外，提取物对黄嘌呤氧化酶表现出一定的抑制活性。黑醋栗提取物活性最高，其花青素和多酚含量最丰富。另一方面，红醋栗提取物似乎比其他粗提物含有更多的活性物质。
