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[R蛋白作为肾脏疾病细胞受体机制紊乱的反映]

[R proteins as a reflection of disorders in the cellular reception mechanisms in kidney diseases].

作者信息

Kozlovskaia L V, Zaĭtseva L I, Karryeva B Ch, Kulagina N N, Artem'eva V B

出版信息

Ter Arkh. 1992;64(4):79-81.

PMID:1332207
Abstract

As many as 47 patients with amyloidosis and 31 with chronic glomerulonephritis (CGN) were examined for the blood serum content of R proteins, chemotactic activity of blood leukocytes and the degree of the inhibitory influence of the autologous serum on chemotaxis. Amyloidosis and CGN were marked by an increase of the level of receptor proteins. A reverse correlation was established between the rise of the content of R proteins and the chemotactic properties of leukocytes. In CGN, the rate of demonstration of the high titers of R proteins and the magnitude of the chemotaxis decline depended on the disease phase (the degree of activity) whereas in amyloidosis, these reactions differed insignificantly in patients with various clinical patterns and stages of renal amyloidosis.

摘要

对多达47例淀粉样变性患者和31例慢性肾小球肾炎(CGN)患者进行了血清R蛋白含量、血液白细胞趋化活性以及自体血清对趋化性抑制影响程度的检测。淀粉样变性和CGN的特征是受体蛋白水平升高。R蛋白含量的增加与白细胞的趋化特性之间存在负相关。在CGN中,高滴度R蛋白的显示率和趋化性下降的幅度取决于疾病阶段(活动程度),而在淀粉样变性中,不同临床类型和肾淀粉样变性阶段的患者这些反应差异不显著。

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1
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Ter Arkh. 1992;64(4):79-81.
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