Rivier C, Rivier J, Vale W
Endocrinology. 1978 Dec;103(6):2299-305. doi: 10.1210/endo-103-6-2299.
LRF and one of its highly potent analogs, [D-Trp6-Pro9-NEt]LRF (A), were tested for their effects on pregnancy. Daily doses of A prevented implantation and/or caused resorption of implanted blastocysts in mated female rats. This effect was dose related and was most evident when given in regimens including days 5-7 or days 9-10 or pregnancy. LRF also has antigonadal effects, but at much higher doses than A. The use of corn oil vs. 0.1% gelatin-saline improved the effectiveness of low doses of A. Termination of pregnancy in A- or LRF-treated rats is most probably due to the markedly diminished progesterone secretion, which could result from the secretion of biologically inactive gonadotropins, reduced pituitary responsiveness to endogenous LRF, or down-regulation of gonadal receptors for LH.
促黄体释放因子（LRF）及其一种高效类似物[D-色氨酸6-脯氨酸9-乙胺基]LRF（A），针对它们对妊娠的影响进行了测试。每天给予A可阻止已交配雌性大鼠的着床和/或导致已着床胚泡的吸收。这种效应与剂量相关，在包括妊娠第5 - 7天或第9 - 10天的给药方案中最为明显。LRF也有抗性腺作用，但所需剂量比A高得多。使用玉米油与0.1%明胶 - 生理盐水相比，提高了低剂量A的有效性。经A或LRF处理的大鼠妊娠终止，很可能是由于孕酮分泌显著减少，这可能是由于生物活性促性腺激素分泌减少、垂体对内源性LRF的反应性降低或性腺对促黄体生成素（LH）受体的下调所致。
