人小细胞肺癌在SCID小鼠静脉移植后的原位重建
Orthotopic reconstitution of human small-cell lung carcinoma after intravenous transplantation in SCID mice.
作者信息
Kuo T H, Kubota T, Watanabe M, Furukawa T, Kase S, Tanino H, Nishibori H, Saikawa Y, Teramoto T, Ihsibiki K
机构信息
Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
出版信息
Anticancer Res. 1992 Sep-Oct;12(5):1407-10.
We have constructed an orthotopically reconstituted model of human small-cell lung carcinoma (SCLC) by intravenous transplantation in severe combined immunodeficient (SCID) mice. Two human SCLC xenografts, H-69 and Lu-130, were disaggregated and injected through the tail vein of SCID mice. Human SCLCs were orthotopically reconstituted with multi-focal lung tumor growth in all SCID mice after intravenous injection of 5 x 10(6) tumor cells per mouse. The heart and liver were also seeded with actively growing SCLC. This orthotopic reconstitution model of human SCLC in SCID mice should be useful for further studies on the biological behavior and treatment of human SCLC.
我们通过在严重联合免疫缺陷（SCID）小鼠中进行静脉移植，构建了人小细胞肺癌（SCLC）的原位重建模型。将两个人SCLC异种移植瘤H-69和Lu-130进行解离，并通过SCID小鼠的尾静脉注射。在每只小鼠静脉注射5×10⁶个肿瘤细胞后，所有SCID小鼠均原位重建了多灶性肺肿瘤生长的人SCLC。心脏和肝脏也接种了生长活跃的SCLC。这种SCID小鼠中人SCLC的原位重建模型应有助于进一步研究人SCLC的生物学行为和治疗。
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