Kubota T
Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
J Cell Biochem. 1994 Sep;56(1):4-8. doi: 10.1002/jcb.240560103.
Metastatic model of human tumor xenografts have been developed using orthotopic transplantation of histologically intact tissue (onplantation) of lung, stomach, colon, pancreatic, prostate and bladder carcinomas. These models represent the entire process of the metastasis, consisting of local tumor growth, vascular and lymphatic invasion at the local site, flow in the vessels and lymphatic, extravasation at the metastatic organs, and seeding and growth at relevant metastatic sites. Orthotopically transplanted human small-cell lung carcinoma displayed a different chemosensitivity pattern compared with the subcutaneous transplanted model, suggesting different pharmacodynamics between the orthotopic lung and the ectopic subcutaneous sites. The intact-tissue orthotopic-onplantation model seems to be useful to study the mechanism of metastasis for discovery of antimetastatic agents and for the patient tumors and for this treatment design.
已通过对肺癌、胃癌、结肠癌、胰腺癌、前列腺癌和膀胱癌的组织学完整组织进行原位移植（植入），建立了人肿瘤异种移植的转移模型。这些模型代表了转移的整个过程，包括局部肿瘤生长、局部血管和淋巴管浸润、血管和淋巴管内流动、转移器官处的外渗以及相关转移部位的播种和生长。与皮下移植模型相比，原位移植的人小细胞肺癌表现出不同的化学敏感性模式，这表明原位肺和异位皮下部位之间存在不同的药效学。完整组织原位植入模型似乎有助于研究转移机制，以发现抗转移药物、用于患者肿瘤和治疗设计。
