Fedorov V I
Fiziol Zh SSSR Im I M Sechenova. 1992 Jun;78(6):79-85.
I. v. administration of carbachol or neostigmine produced a dose-dependent decrease in the angiotensin I pressor response and in conversion of angiotensin I to angiotensin II in anesthetized rats. Physostigmine produced the same effects in combination with propranolol. Administration of cholinomimetics with atropine leads to no such effect. The activation of the cholinergic system seems to inhibit a formation of angiotensin II.
静脉注射卡巴胆碱或新斯的明可使麻醉大鼠体内血管紧张素I的升压反应以及血管紧张素I向血管紧张素II的转化呈剂量依赖性降低。毒扁豆碱与普萘洛尔联合使用时也产生同样的效果。胆碱能拟似药与阿托品联合使用则不会产生这种效果。胆碱能系统的激活似乎会抑制血管紧张素II的形成。
