[血管紧张素升压反应的胆碱能调制]

[The cholinergic modulation of the pressor reaction to angiotensin].

作者信息

Fedorov V I

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1991 Jul;77(7):57-62.

Abstract

I.v. administration of acetylcholine or acetylcholine plus neostigmine produced a dose-dependent decrease of angiotensin pressor response to 59.2, 39.9, and 26.8% of basal level at 10(-7), 10(-6), and 10(-5) M/kg, resp., and to 76.4 and 56.7% of basal level at 10(-6) and 10(-5) M/kg of neostigmine in anesthetized rats. Atropine prevented these effects and increased the angiotensin pressor response to 142.1 and 168.9% of basal level at 10(-7) and 10(-6) M/kg, resp., in intact rats. The cholinergic system seems to attenuate angiotensin effect on arterial pressure.

摘要

静脉注射乙酰胆碱或乙酰胆碱加新斯的明，在麻醉大鼠中，以10(-7)、10(-6)和10(-5)M/kg的剂量分别使血管紧张素升压反应降至基础水平的59.2%、39.9%和26.8%，而在新斯的明剂量为10(-6)和10(-5)M/kg时，分别降至基础水平的76.4%和56.7%。阿托品可预防这些作用，并在完整大鼠中，以10(-7)和10(-6)M/kg的剂量分别使血管紧张素升压反应增加至基础水平的142.1%和168.9%。胆碱能系统似乎减弱了血管紧张素对动脉血压的作用。