先天性巨结肠症：病毒病因？

Hirschsprung's disease: a viral etiology?

作者信息

Tam P K, Quint W G, van Velzen D

机构信息

Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, United Kingdom.

出版信息

Pediatr Pathol. 1992 Nov-Dec;12(6):807-10. doi: 10.3109/15513819209024237.

DOI:10.3109/15513819209024237

PMID:1333073

Abstract

This study investigates the hypothesis that Hirschsprung's disease (HD), congenital rectal aganglionosis, may be etiologically linked to antenatal cytomegalovirus (CMV) infection. Bowel specimens from 72 HD patients, 144 control I infants (Hirschsprung-like symptoms, normal histology), and 36 control II infants (deaths from nongastrointestinal causes) were analyzed for CMV genomes by polymerase chain reaction. Positive results were obtained in 6 HD patients (8.8%) and none of the controls. Our findings suggest that antenatal CMV infection, a potentially preventable condition, may be one of the etiological factors in HD.

摘要

本研究调查了一种假说，即先天性巨结肠症（HD），也就是先天性直肠无神经节症，可能在病因上与产前巨细胞病毒（CMV）感染有关。通过聚合酶链反应对72例HD患者、144例对照I婴儿（有先天性巨结肠样症状，组织学正常）和36例对照II婴儿（死于非胃肠道原因）的肠道标本进行CMV基因组分析。6例HD患者（8.8%）检测结果呈阳性，而对照组均为阴性。我们的研究结果表明，产前CMV感染是一种潜在可预防的情况，可能是HD的病因之一。