Smith B R, Robidoux J, Amit Z
Center for Studies in Behavioural Neurobiology, Concordia University, Montreal, Quebec, Canada.
Alcohol Alcohol. 1992 May;27(3):227-31.
Treatment with the GABAA agonist THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) or the GABAB agonist baclofen was shown to enhance the acquisition of voluntary ethanol consumption in laboratory rats. THIP administration resulted in an increased intake of absolute ethanol without an increase in total fluid intake. In contrast, baclofen administration, while increasing ethanol intake in a manner similar to that seen with THIP, also increased total fluid intake, indicating that its effects may not be specific to an interaction with ingested ethanol. The data obtained in the present study support the notion that GABAergic mechanisms, particularly those related to the GABAA receptor, may be involved in the acquisition of voluntary ethanol consumption in laboratory rats.
用GABAA激动剂THIP（4,5,6,7 - 四氢异恶唑并[5,4 - c]吡啶 - 3 - 醇）或GABAB激动剂巴氯芬进行治疗，已证明可增强实验大鼠自愿摄入乙醇的习得。给予THIP导致绝对乙醇摄入量增加，而总液体摄入量未增加。相比之下，给予巴氯芬虽然以与THIP相似的方式增加乙醇摄入量，但也增加了总液体摄入量，这表明其作用可能并非特异性地与摄入的乙醇相互作用。本研究获得的数据支持这样一种观点，即GABA能机制，特别是那些与GABAA受体相关的机制，可能参与实验大鼠自愿摄入乙醇的习得过程。
