Hyde T M, Wu L C, Krasnov I B, Sigworth S K, Daunton N G, D'Amelio F
Clinical Brain Disorders Branch, NIMH, St. Elizabeth's, Washington, DC 20032.
Brain Res. 1992 Oct 16;593(2):291-4. doi: 10.1016/0006-8993(92)91321-5.
The quantitative autoradiographic analysis of muscarinic cholinergic and GABAA (benzodiazepine) receptors was performed on selected regions of the cerebral cortex and striatum of rats flown in the Soviet Biosatellite COSMOS 2044. An age- and strain-matched synchronous ground-based control group was employed for comparison. Muscarinic cholinergic receptor density was found to be significantly lower in the striatum of the flight animals as compared with that in the synchronous control group. No significant differences between flight and synchronous control groups were found in the other regions examined. GABAA (benzodiazepine) receptors showed no significant differences between the flight and control groups in any of the regions sampled. Although additional studies are needed to reach definitive conclusions, the decrease in muscarinic cholinergic receptors observed in the striatum suggests spaceflight-related alterations in motor activity.
对搭乘苏联生物卫星COSMOS 2044飞行的大鼠大脑皮层和纹状体的选定区域进行了毒蕈碱型胆碱能受体和GABAA（苯二氮䓬）受体的定量放射自显影分析。采用年龄和品系匹配的同步地面对照组进行比较。结果发现，与同步对照组相比，飞行大鼠纹状体中毒蕈碱型胆碱能受体密度显著降低。在所检查的其他区域，飞行组与同步对照组之间未发现显著差异。在任何采样区域，飞行组和对照组之间的GABAA（苯二氮䓬）受体均未显示出显著差异。尽管需要进一步研究才能得出明确结论，但纹状体中观察到的毒蕈碱型胆碱能受体减少表明与太空飞行相关的运动活动改变。
