Soini Y, Kamel D, Nuorva K, Lane D P, Vähäkangas K, Pääkkö P
Department of Pathology, University of Oulu, Finland.
Virchows Arch A Pathol Anat Histopathol. 1992;421(5):415-20. doi: 10.1007/BF01606914.
Fifty-one salivary gland tumours (23 pleomorphic adenomas, 5 Warthin's tumours, 12 mucoepidermoid carcinomas, 7 adenoid cystic carcinomas, 3 undifferentiated carcinomas and 1 acinic cell tumour) and 27 lung carcinomas (18 squamous cell carcinomas) were analysed immunohistochemically for the expression of p53 nuclear phosphoprotein. Eight out of 51 (16%) salivary gland tumours were p53 positive. Three of these were benign and 5 malignant. All 3 benign salivary gland tumours were pleomorphic adenomas and expressed only occasional nuclear positivity with less than 1% of tumour cells positive. Of the 5 p53-positive malignant tumours, 3 were mucoepidermoid carcinomas and 2 undifferentiated carcinomas. The malignant salivary gland tumours expressed more than 1% of positive nuclei in every case. Seventeen lung carcinomas were p53 positive (63%). Thirteen of these were squamous cell carcinomas, 3 were adenocarcinomas and 1 small cell lung carcinoma. The results show that mutations of the p53 gene may be infrequent in salivary gland tumours when compared with lung carcinomas. The relatively indolent course of some histological types of malignant salivary gland tumours could be associated with the preservation of the non-mutated p53 gene in most of these tumours. The presence of p53 positivity in some pleomorphic adenomas might, on one hand, suggest that p53 gene alterations are also present in these tumours; on the other hand, the accumulation of the p53 protein in these tumours might also be due to some unknown mechanism, not necessarily related to p53 gene mutation.
对51例涎腺肿瘤（23例多形性腺瘤、5例沃辛瘤、12例黏液表皮样癌、7例腺样囊性癌、3例未分化癌和1例腺泡细胞癌）和27例肺癌（18例鳞状细胞癌）进行免疫组织化学分析，以检测p53核磷蛋白的表达。51例涎腺肿瘤中有8例（16%）p53呈阳性。其中3例为良性，5例为恶性。所有3例良性涎腺肿瘤均为多形性腺瘤，仅偶尔出现核阳性，阳性肿瘤细胞少于1%。在5例p53阳性的恶性肿瘤中，3例为黏液表皮样癌，2例为未分化癌。每例恶性涎腺肿瘤的阳性细胞核均超过1%。17例肺癌p53呈阳性（63%）。其中13例为鳞状细胞癌，3例为腺癌，1例为小细胞肺癌。结果表明，与肺癌相比，p53基因在涎腺肿瘤中的突变可能较少见。某些组织学类型的恶性涎腺肿瘤病程相对缓慢，可能与这些肿瘤中大多数保留未突变的p53基因有关。一些多形性腺瘤中存在p53阳性，一方面可能提示这些肿瘤中也存在p53基因改变；另一方面，这些肿瘤中p53蛋白的积累也可能是由于某些未知机制，不一定与p53基因突变有关。
