University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Head Neck. 2012 Nov;34(11):1665-77. doi: 10.1002/hed.21849. Epub 2011 Oct 17.
Adenoid cystic carcinoma (ACC) is an unusual salivary gland malignancy that remains poorly understood. Standard treatment, including surgery with postoperative radiation therapy, has attained reasonable local control rates, but the propensity for distant metastases has limited any improvement in survival over time. Our understanding of the molecular mechanisms driving ACC is quite rudimentary, due to the infrequent nature of its occurrence.
An extensive literature review was performed on salivary gland ACCs and basic science research findings.
This review highlights many findings that are emerging about the carcinogenesis of ACC including cytogenetics, tumor suppressor genes, oncogenes, epigenetic alterations, mitochondrial alterations, and biomarker studies.
Although there have been many discoveries, much still remains unknown about this rare malignancy. © 2011 Wiley Periodicals, Inc. Head Neck, 2011.
腺样囊性癌（ACC）是一种不常见的唾液腺癌，目前仍知之甚少。包括术后放疗在内的标准治疗已取得了合理的局部控制率，但远处转移的倾向限制了生存时间的任何改善。由于其罕见的发生，我们对驱动 ACC 的分子机制的了解还相当初步。
对唾液腺癌 ACC 和基础科学研究结果进行了广泛的文献复习。
本综述强调了许多关于 ACC 发生的新兴发现，包括细胞遗传学、肿瘤抑制基因、癌基因、表观遗传改变、线粒体改变和生物标志物研究。
尽管已经有了许多发现，但对于这种罕见的恶性肿瘤，仍有很多未知之处。©2011 年 Wiley 期刊，头颈部，2011 年。
