Mazzocchi G, Malendowicz L K, Rocco S, Musajo F, Nussdorfer G G
Department of Anatomy, University of Padua, Italy.
Neuropeptides. 1993 Feb;24(2):105-8. doi: 10.1016/0143-4179(93)90028-9.
Acute and chronic systemic administrations of neurotensin (NT) and arginine-vasopressin (AVP) significantly increases plasma aldosterone concentration (PAC) in rats. Deamino-Pen1, Val4, D-Arg8-vasopressin (AVP-A), a potent AVP antagonist, completely reversed both acute and chronic aldosterone secretagogue actions of NT and AVP. AVP-A acute administration did not affect basal PAC, while chronic AVP-A treatment significantly lowered it. Taken together our findings suggest that both NT and AVP exert a marked aldosterone secretagogue effect in rats, and that the mechanism underlying NT action may involve the stimulation of AVP release. Moreover, they indicate that endogenous AVP plays an essential role in the maintenance of the mineralocorticoid secretory capacity of rat zona glomerulosa.
对大鼠进行神经降压素（NT）和精氨酸加压素（AVP）的急性和慢性全身给药，可显著提高其血浆醛固酮浓度（PAC）。强效AVP拮抗剂去氨基 - Pen1、Val4、D - Arg8 - 加压素（AVP - A）完全逆转了NT和AVP的急性和慢性醛固酮促分泌作用。急性给予AVP - A不影响基础PAC，而长期给予AVP - A治疗则显著降低基础PAC。综合我们的研究结果表明，NT和AVP在大鼠中均发挥显著的醛固酮促分泌作用，且NT作用的潜在机制可能涉及刺激AVP释放。此外，研究结果表明内源性AVP在维持大鼠肾小球带盐皮质激素分泌能力方面发挥着重要作用。
