Ng L L, Davies J E
Department of Pharmacology, Leicester Royal Infirmary, United Kingdom.
J Am Soc Nephrol. 1992 Oct;3(4 Suppl):S50-5. doi: 10.1681/ASN.V34s50.
In hypertensive humans and the spontaneously hypertensive rat, increased cellular Na+/H+ antiport activity has been demonstrated in leukocytes, platelets, skeletal muscle, and vascular smooth muscle cells. This membrane abnormality may be associated with medial thickening of resistance vessels. A similar membrane transport abnormality has also been demonstrated in leukocytes and fibroblasts from type 1 diabetic patients with nephropathy. This membrane transport marker of hypertension may indicate a predisposition to essential hypertension in such patients and may lead to diabetic nephropathy, possibly from mesangial expansion.
在高血压患者和自发性高血压大鼠中，已证实在白细胞、血小板、骨骼肌和血管平滑肌细胞中，细胞的钠/氢反向转运活性增加。这种膜异常可能与阻力血管的中层增厚有关。在患有肾病的1型糖尿病患者的白细胞和成纤维细胞中也证实了类似的膜转运异常。这种高血压的膜转运标志物可能表明此类患者易患原发性高血压，并可能导致糖尿病肾病，可能是由于系膜扩张所致。
