Brisigotti M, Cozzutto C, Fabbretti G, Sergi C, Callea F
Department of Pathology, Gaslini Research Children's Hospital, Genoa, Italy.
Histol Histopathol. 1992 Oct;7(4):689-92.
In a recent survey of more than one hundred childhood renal tumors in our Laboratory files, we identified a unique case characterized by an unusual degree of differentiation and cell maturity. Histologically this case was notable for an orderly array of small and uniformly-packed tubules with a rosette-like configuration. The nuclei were oval, smooth and of a bland appearance. Mitoses were absent. Many glomerular figures were intermingled. This renal tumor picture is somewhat different from that known as tubular Wilms' tumor because of the well-differentiated adenomatous pattern and the absence of any blastema. The term metanephric adenoma is suggested for this tumor, which may represent the benign counterpart of Wilms' tumor.
在我们实验室档案中近期对一百多例儿童肾肿瘤的调查中，我们发现了一个独特病例，其特征为分化程度和细胞成熟度异常。组织学上，该病例的显著特点是有排列有序的小而紧密排列的小管，呈玫瑰花结样结构。细胞核呈椭圆形，表面光滑，外观温和。未见有丝分裂。有许多肾小球样结构相互交织。这种肾肿瘤表现与所谓的肾小管性威尔姆斯瘤有所不同，因为其具有分化良好的腺瘤样模式且无任何胚基。建议将此肿瘤命名为后肾腺瘤，它可能代表威尔姆斯瘤的良性对应物。
