Chen S C, Lian S L, Chuang W L, Hsieh M Y, Wang L Y, Chang W Y, Ho Y H
Department of Internal Medicine, Kaohsiung Medical College, Taiwan, R.O.C.
Cancer Chemother Pharmacol. 1992;31 Suppl:S103-5. doi: 10.1007/BF00687117.
A study was conducted to evaluate the effect of external radiation therapy on hepatocellular carcinoma (HCC) and its metastatic lesions. A total of 33 patients with cytopathologically proven HCC were subjected to radiation therapy over a 4-year period, and treatment was discontinued in 8 cases due to jaundice, severe discomfort, or early mortality. Thus, 25 patients with 28 lesions underwent irradiation with a total dose ranging between 3000 and 5600. Of these, seven were irradiated for liver tumors, and the results showed that two lesions decreased in size, the symptoms improved in 1 case, and another patient maintained stable disease for 4 months. Among the 21 metastatic lesions treated, only 2 patients failed respond to the treatment. Nine subjects were irradiated for bone metastases, and the bone pain subsided in all but one case. The survival for bone metastasis was as long as 23 months when the primary tumor was treated effectively. Three of the four cases of irradiated skin nodules disappeared and had not recurred after 5 months, 1 year, and 4 years, respectively. Tumor shrinkage or symptoms of relief were noted for three abdominal lymph nodes, one neck lymph node, one pleural tumor, and one lung tumor. Clinical improvement associated with a stable lesion was observed in two patients with brain metastasis. Follow-up revealed regrowth of the tumor or recurrence of symptoms in most of the patients. However, none of the patients died as a direct result of a metastatic lesion. Although external radiation therapy is palliative in intent, it appears to be useful in the treatment of HCC and its metastatic lesions.
开展了一项研究以评估外照射疗法对肝细胞癌（HCC）及其转移病灶的疗效。在4年期间，共有33例经细胞病理学证实为HCC的患者接受了放射治疗，其中8例因黄疸、严重不适或早期死亡而停止治疗。因此，25例患者的28个病灶接受了总剂量在3000至5600之间的照射。其中，7个病灶为肝脏肿瘤，结果显示2个病灶缩小，1例症状改善，另1例患者病情稳定4个月。在接受治疗的21个转移病灶中，只有2例患者治疗无效。9例患者接受了骨转移照射，除1例之外所有患者的骨痛均缓解。当原发肿瘤得到有效治疗时，骨转移患者的生存期长达23个月。4例接受照射的皮肤结节中有3例分别在5个月、1年和4年后消失且未复发。3个腹部淋巴结、1个颈部淋巴结、1个胸膜肿瘤和1个肺部肿瘤出现了肿瘤缩小或症状缓解。2例脑转移患者出现了与病灶稳定相关的临床改善。随访发现大多数患者肿瘤复发或症状复发。然而，没有患者因转移病灶直接死亡。尽管外照射疗法旨在缓解症状，但它似乎对HCC及其转移病灶的治疗有用。
