Toshikuni Nobuyuki, Morii Kazuhiko, Yamamoto Michinori
Department of Internal Medicine, Center for Liver Diseases, Kawasaki Hospital, Kawasaki Medical School, 2-1-80 Nakasange, Okayama, Japan.
World J Gastroenterol. 2007 Sep 7;13(33):4520-2. doi: 10.3748/wjg.v13.i33.4520.
A 78-year-old man with liver cirrhosis was found to have multiple hepatocellular carcinomas (HCCs) and underwent 3 sessions of transcatheter arterial chemoembolization. Fourteen months after diagnosis, the patient presented with left hemiparesis. Contrast-enhanced magnetic resonance imaging showed multiple metastases with ring-shaped enhancement in the cerebrum and cerebellum. There were no metastases to other organs. The metastatic lesions almost completely disappeared after whole-brain radiotherapy with a total dose of 50 Gy. Neurologic symptoms decreased, and the patient's quality of life improved. The patient underwent 2 more sessions of transcatheter arterial chemoembolization. Twelve months after the diagnosis of brain metastasis, the patient remains alive. The present case indicates that radiotherapy can improve quality of life and prolong survival in some patients with brain metastases from HCCs.
一名78岁的肝硬化男性被发现患有多发性肝细胞癌（HCC），并接受了3次经动脉化疗栓塞术。诊断后14个月，患者出现左侧偏瘫。对比增强磁共振成像显示大脑和小脑有多个环形强化的转移灶。无其他器官转移。全脑放疗总剂量50 Gy后，转移灶几乎完全消失。神经症状减轻，患者生活质量改善。患者又接受了2次经动脉化疗栓塞术。脑转移诊断后12个月，患者仍然存活。本病例表明，放疗可改善部分HCC脑转移患者的生活质量并延长生存期。
