Vasiliu M, Stratulat L, Pahomeanu M, Dimitriu C, Chelaru M
Rev Chir Oncol Radiol O R L Oftalmol Stomatol Chir. 1976 Mar-Apr;25(2):121-6.
Malignization of Crohn disease remains the most severe complication, both due to its intrinsic gravity and to the major complications that it may induce such as: peritonitis--following suppurations and perforation of the involved intestinal segment; intestinal sub-occlusion or mechano-inflammatory occlusion, either tumoral or chronic leading to stenosis of the intestine; hemorrhage. Malignization of Crohn disease was found in 53,84% of the cases (7 out of a total of 13 cases, between 1968 and 1974). This allows to conclude that Crohn disease can be considered as a pre-cancerous disease.