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角鲨烯对12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯在小鼠皮肤致癌作用中促肿瘤活性的抑制作用。

Inhibition by squalene of the tumor-promoting activity of 12-O-tetradecanoylphorbol-13-acetate in mouse-skin carcinogenesis.

作者信息

Murakoshi M, Nishino H, Tokuda H, Iwashima A, Okuzumi J, Kitano H, Iwasaki R

机构信息

Department of Biochemistry, Kyoto Prefectural University of Medicine, Japan.

出版信息

Int J Cancer. 1992 Dec 2;52(6):950-2. doi: 10.1002/ijc.2910520620.

DOI:10.1002/ijc.2910520620
PMID:1334056
Abstract

Squalene inhibited the effect of tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), such as increased 32Pi incorporation into phospholipids of HeLa cell membrane, induction of Epstein-Barr-virus early antigen in Raji cell and induction of ornithine decarboxylase in mouse skin. Squalene also markedly suppressed the promoting activity of TPA on skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated mice.

摘要

角鲨烯抑制肿瘤启动子12-O-十四酰佛波醇-13-乙酸酯（TPA）的作用，如增加32Pi掺入HeLa细胞膜磷脂中、诱导Raji细胞中EB病毒早期抗原以及诱导小鼠皮肤中的鸟氨酸脱羧酶。角鲨烯还显著抑制TPA对7,12-二甲基苯并[a]蒽引发的小鼠皮肤致癌作用的促进活性。

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