Os I, Bratland B, Dahlöf B, Gisholt K, Syvertsen J O, Tretli S
Nyreavdelingen, Medisinsk klinikk, Ullevål sykehus, Oslo.
Tidsskr Nor Laegeforen. 1992 Nov 10;112(27):3429-31.
In a Norwegian, double-blind, double-dummy multicenter study, 828 patients with mild to moderate hypertension were randomized to treatment by either lisinopril or nifedipine. One of the aims of the study was to specifically investigate the frequency of side effects. Spontaneously reported coughing reached 8.5% for lisinopril, as against 3.1% for nifedipine. In two patients coughing led to withdrawal from the study, and in another three it contributed partially to discontinuation of the treatment. A significant sex difference was found for spontaneously reported coughing among patients on lisinopril; 12.6% of the women and 4.4% of the men. A similar difference between the sexes was found for specific questioning about coughing. Use of a visual analogue scale by both patient and spouse revealed similar frequency of coughing as when reported spontaneously. The reason for sex being an important determinant for lisinopril-induced coughing remains obscure.
在挪威进行的一项双盲、双模拟、多中心研究中，828例轻至中度高血压患者被随机分为接受赖诺普利或硝苯地平治疗。该研究的目的之一是专门调查副作用的发生频率。自发报告的咳嗽发生率在接受赖诺普利治疗的患者中达到8.5%，而接受硝苯地平治疗的患者为3.1%。有2例患者因咳嗽退出研究，另有3例患者部分因咳嗽而停药。在接受赖诺普利治疗的患者中，自发报告的咳嗽存在显著的性别差异；女性为12.6%，男性为4.4%。在针对咳嗽进行具体询问时，也发现了类似的性别差异。患者及其配偶使用视觉模拟量表显示，咳嗽频率与自发报告时相似。性别成为赖诺普利引起咳嗽的重要决定因素的原因尚不清楚。
