我们知道环孢素的作用部位吗？
Do we know the site of action of cyclosporin?
作者信息
Erlanger B F
机构信息
Dept of Microbiology, Columbia University Health Sciences Center, New York, NY 10032.
出版信息
Immunol Today. 1992 Dec;13(12):487-90. doi: 10.1016/0167-5699(92)90023-Z.
PMID:1334415
Abstract
The site and mode of action of cyclosporin A (CsA) have been subjects of study ever since CsA was discovered and demonstrated to be a selective suppressor of allograft rejection. In this article, Bernard Erlanger traces progress to date and presents evidence that the site of action is not cytoplasmic cyclophilin but a lymphocyte cell-surface receptor that might be related in structure to cyclophilin.
摘要
自从环孢素A（CsA）被发现并被证明是同种异体移植排斥反应的选择性抑制剂以来，其作用部位和作用方式一直是研究的课题。在本文中，伯纳德·埃尔朗热追溯了迄今为止的研究进展，并提出证据表明其作用部位不是细胞质亲环蛋白，而是一种淋巴细胞细胞表面受体，其结构可能与亲环蛋白有关。
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