Liao D, Jones A, Malinow R
Department of Physiology and Biophysics, University of Iowa, Iowa City 52242.
Neuron. 1992 Dec;9(6):1089-97. doi: 10.1016/0896-6273(92)90068-o.
The modification responsible for the long-term synaptic potentiation (LTP) that follows a brief conditioning period is not known. To elucidate this change, we have resolved quantal levels of transmission before and after induction of LTP. We find an increase both in the number of quanta released and in quantal amplitude, consistent with combined pre- and postsynaptic modifications. On average, about 60% of LTP can be accounted for by presynaptic enhancement. The increase in either quantal amplitude or quantal content varies significantly among different experiments, but is inversely correlated with its initial value. These results may help to reconcile the different views concerning the site of LTP expression.
在短暂的条件刺激期后引起长期突触增强（LTP）的修饰尚不明确。为阐明这一变化，我们测定了LTP诱导前后的量子传递水平。我们发现释放的量子数量和量子幅度均增加，这与突触前和突触后的联合修饰一致。平均而言，约60%的LTP可由突触前增强来解释。量子幅度或量子含量的增加在不同实验中差异显著，但与其初始值呈负相关。这些结果可能有助于调和关于LTP表达位点的不同观点。
