Isaac J T, Oliet S H, Hjelmstad G O, Nicoll R A, Malenka R C
Department of Psychiatry, University of California, San Francisco 94143-0984, USA.
J Physiol Paris. 1996;90(5-6):299-303. doi: 10.1016/s0928-4257(97)87901-6.
We have taken a number of different experimental approaches to address whether long-term potentiation (LTP) in hippocampal CA1 pyramidal cells is due primarily to presynaptic or postsynaptic modifications. Examination of miniature EPSCs or EPSCs evoked using minimal stimulation indicate that quantal size increasing during LTP. The conversion of silent to functional synapses may contribute to the LTP-induced changes in mEPSC frequency and failure rate that previously have been attributed to an increase in the probability if transmitter release.
我们采用了多种不同的实验方法来探讨海马体CA1锥体细胞中的长时程增强（LTP）主要是由突触前还是突触后修饰引起的。对微小兴奋性突触后电流（mEPSCs）或使用最小刺激诱发的兴奋性突触后电流（EPSCs）的检测表明，在LTP期间量子大小增加。沉默突触向功能性突触的转变可能有助于LTP诱导的mEPSC频率和失败率的变化，此前这些变化被归因于递质释放概率的增加。
