Hoff G, Moen I E, Mowinckel P, Rosef O, Nordbö E, Sauar J, Vatn M H, Torgrimsen T
Medical Department, Telemark Sentralsykehus, Skien, Norway.
Eur J Cancer Prev. 1992 Oct;1(6):423-8. doi: 10.1097/00008469-199210000-00005.
This study was based on an endoscopic screening study for detection of polyps in the rectum and sigmoid colon in a randomized, normal population sample of 400 individuals aged 50-59 years. Family disposition for cancer and indicators of lifestyle (including dietary registration) were recorded. The 310 individuals received domestic drinking water from one out of four public water supplies. The participants were categorized according to the water supply connected to their house of residence. Drinking water was analysed monthly during 2 years for chloroform, total organic carbon, colour index, calcium, magnesium and chlorine. The overall prevalence of colorectal polyps was significantly higher in residents receiving chlorinated water with a high organic content when compared with recipients of water with a low organic content. There was no association between polyp prevalence and chloroform concentration in the drinking water. Multivariate analysis revealed that age, male sex, high BMI, smoking, few stools per week, high protein intake and low intake of fibre, iron and cruciferous vegetables were far more important for the presence of polyps than the total organic content in chlorinated drinking water.
本研究基于一项针对400名年龄在50至59岁的随机正常人群样本进行的直肠和乙状结肠息肉内镜筛查研究。记录了癌症家族倾向和生活方式指标（包括饮食记录）。310名个体从四个公共供水系统中的一个获取生活饮用水。参与者根据其居住房屋所连接的供水系统进行分类。在两年时间里每月对饮用水进行分析，检测氯仿、总有机碳、颜色指数、钙、镁和氯。与饮用低有机含量水的居民相比，饮用高有机含量氯化水的居民中大肠息肉的总体患病率显著更高。息肉患病率与饮用水中氯仿浓度之间没有关联。多变量分析显示，对于息肉的存在而言，年龄、男性、高体重指数、吸烟、每周排便次数少、高蛋白摄入以及低纤维、铁和十字花科蔬菜摄入量比氯化饮用水中的总有机含量重要得多。
